A biofilm is an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix, and the most adaptable microbial feature in nature. However, when the associated microbes are pathogenic, this ability to aggregate into biofilms becomes a significant virulence factor. Biofilms play an important role in infections due to their high tolerance to a broad range of antimicrobials. The vast majority of biofilm mediated infections are related to medical devices (e.g. knee replacements, catheters, implants etc) or tissue related (e.g. chronic wounds, endocarditis, chronic otitis media etc).
Biofilm formation is responsible for the development of superbugs like MRSA, VRSA, and MBL producing.
The article discusses the importance of understanding the biofilm- antibiotic resistance pathology and the need to create awareness around it.
Link to the article: bit.ly/3SQFSR3
Published On: 07/03/2023