Neonatal sepsis is a major cause of neonatal mortality and therefore a significant global health issue. E.coli is usually the leading pathogen in neonatal sepsis, especially in premature infants. Extended Spectrum Beta Lactamase (ESBLs) are often located on large plasmids that also harbor genes resistant to other antimicrobial classes, resulting in Multi Drug resistant (MDR) isolates. The authors in this study explore the risk factors associated with ESBL-producing MDR E.coli among neonates and thereby to help selection of appropriate empirical antibiotics. They further observed that higher proportion of ESBL-producing MDR E.coli are seen in premature infants and those newborns with Hospital Acquired late Onset sepsis. The mortality rate of neonatal sepsis caused by ESBL-producing E.coli is twice as high as that of sepsis caused by ESBL-negative E.coli Furthermore, antepartum use of cephalosporins and prolonged use of parenteral nutrition may be important factors to consider in the selection of sensitive empirical antibiotics for use in neonatal sepsis.
Link to the article: bit.ly/3UorJuY
Published On: /04/2023
