Obstructive sleep apnea (OSA) leads to intermittent hypoxia and sleep fragmentation. A study was conducted using human specimens to construct a model to demonstrate that OSA can cause significant alterations in the structure of the intestinal flora. The relationship of gut microbiota, intestinal barrier, and Apnea Hypopnea Index was explored and observed that the microbiota characteristics in the severe OSA group were significantly correlated with the intestinal barrier biomarkers, changes in these microbes may play an important role in multi-system and multi-organ disease. It was further noted that repeated hypoxia due to upper airway obstruction affects the composition of fecal and mucosal adherent microbiota, the nasal microbiome and the Oral microbiota. Further studies on host metabolism regulation by OSA through intestinal flora can be explored.
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Published On: 02/02/2023