Dysbiosis, a disturbance in microbiota composition, can have an impact on host physiology through altered energy harvest, the immune system, metabolic signaling, and inflammatory pathways. Microbiota may be a significant contributor that favors weight gain, fat storage, and insulin resistance.
Gut microbiota may enable increased intestinal absorption by increasing villous vascularization and increased triglyceride storage via modulation of fasting-induced adipose factor. The underlying mechanisms of obesity may include the effects of gut microbiota on fat storage, appetite, absorption of energy, circadian rhythm, and chronic inflammation, all of which can promote obesity. Authors in this study, provide an overview of the current evidence concerning the association between gut microbiota and obesity. They discuss the clinical and preclinical studies that explored the association of obesity and related metabolic disorders with various gut microbiome profiles, and the effects of weight loss interventions with different dietary approaches on gut microbiome and the metabolome.
Link to the article: bit.ly/3HZFADa
Published On: /05/2023
