Brain Awareness Week 2023
Series 7 of 7
Exploring The Impacts Of The Brain-Gut Axis On Health And Their Potential Microbial Therapeutic Strategies.
The Brain-Gut axis, is the bidirectional communication between the central and the enteric nervous system, linking the emotional and cognitive centers of the brain with peripheral intestinal functions.
The gut microbiota holds significant potential as a reservoir for new therapeutic opportunities, with the exciting possibility of targeting and impacting the microbiota-gut-brain axis for treating many disorders in the Brain and Gut health.
To mark the end of Brain Awareness Week 2023, here are the links to a few published articles, that explore the various impacts of the Brain-Gut axis and the potential microbial therapeutic treatment strategies.
- Gut-Brain-Bone Marrow Axis In Hypertension :
Hypertensive stimuli (diet, angiotensin II, salt, stress, and maternal factors) dysregulate the gut-brain-Bone marrow axis, leading to high Blood pressure. Neuroinflammation is particularly evident during hypertension and contributes to increased sympathetic outflow. Bone marrow pro-inflammatory progenitors extravasate to the brain, and contribute to neuroinflammation.
rb.gy/ywmm4u - The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease? :
In Multiple Sclerosis, increased Blood Brain barrier, intestinal permeability, and gut dysbiosis, allow the translocation of microbes and their products from the gut lumen into the lamina propria, thereby promoting inflammation, leading to subsequent demyelination and axonal loss in the Central nervous system.
rb.gy/gyxqsw - When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis :
Alterations in host Circadian rhythmicity have a profound effect on the gut microbiota, potentially leading to a feedback mechanism of gut microbial modulation of further circadian rhythm-dependent activity like metabolism, the endocrine system, immune system and inflammation, psychiatric disorders and neurodegenerative disorders.
rb.gy/8xktt1 - Impact of Contaminants on Microbiota: Linking the Gut-Brain Axis with Neurotoxicity :
Endocrine disruptors, heavy metals, pesticides, and other contaminants have negative effects on gut microbiota, such as energy metabolism disorders. The gut microbiota are also able to metabolize xenobiotic compounds and transform them, they can also regulate the expression of host genes related to this process.
rb.gy/82xcrr - The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target :
Changes in the gut microbiota composition after a stroke are linked to physiological changes and the chronic recovery after stroke. These changes may include, the immune response to stroke, and also potentially direct neuro-modulatory effects by soluble mediators (metabolites) produced by the gut bacteria or via the afferent function of the vagus nerve.
rb.gy/6hvax3 - The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect:
Antidepressant Treatment not only act directly on the nervous system, but also alter the structure of the gut microbiota system. Metabolic products of intestinal microorganisms have synergistic effects on antidepressant effects and pharmacokinetics. Antidepressants along with microbial supplements to maintain good gut health can hence the gut-brain axis, can be a potential treatment for holistic therapeutic effect.
rb.gy/rdgulz - The microbiota-gut-brain axis in sleep disorders:
Gut microbiota regulates sleep-cycle via modulating bacterial metabolites, endocrine signaling, neuronal signaling and immune responses. Sleep loss induces gut microbiota dysbiosis and sleep disorders, both reliably correlate with alteration of gut microbiome composition.
rb.gy/hrjevx - Mechanisms of gut microbiota-immune-host interaction on glucose regulation in type 2 diabetes:
Gut microbiota metabolise food into substances that can affect blood sugar and insulin response. On the other hand, through gastrointestinal receptors, enteroendocrine cells secrete a variety of regulatory peptides, such as ghrelin, GLP-1 and GIP. These regulatory peptides play a role through endocrine mechanisms and neural networks, and regulate glucose and energy metabolism by affecting metabolism, gastrointestinal motility and feeding behavior.
rb.gy/qnjmyn - Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics:
Dysbiosed state of the gut microbiota could upregulate the production of epilepsy-promoting metabolites, the secretion of inflammatory factors, etc. leading to abnormal GABA/glutamate ratio and then induce the epilepsy.
rb.gy/6uymhe - Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders:
Antibiotic-induced dysbiosis is a major factor for occurrence of post-infectious irritable bowel syndrome. Cognitive and mood disorders are also frequent in functional gastrointestinal disorders.
rb.gy/nzsmv2
Source: rb.gy/a7pqui
Published On: 19/03/2023