๐ก The study was aimed at understanding the inhibitory effects of a Desmethyl-phosphinothricin Dipeptide Derivative on the growth of the bacterial strains ๐๐ด๐ค๐ฉ๐ฆ๐ณ๐ช๐ค๐ฉ๐ช๐ข ๐ค๐ฐ๐ญ๐ช ๐ข๐ฏ๐ฅ ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด.
๐ Researchers synthesized a Desmethylphosphinothricin Dipeptide derivative and tested its antibacterial activity using controlled growth studies and monitoring against ๐๐ด๐ค๐ฉ๐ฆ๐ณ๐ช๐ค๐ฉ๐ช๐ข ๐ค๐ฐ๐ญ๐ช ๐ข๐ฏ๐ฅ ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด.
๐ L-Leu-D, L-Glu-ฮณ-PH, a dipeptide derivative of desmethylphosphinothricin or Glu-ฮณ-PH, was synthesized and found to inhibit ๐๐ด๐ค๐ฉ๐ฆ๐ณ๐ช๐ค๐ฉ๐ช๐ข ๐ค๐ฐ๐ญ๐ช ๐ข๐ฏ๐ฅ growth effectively.
The synthesized dipeptide exhibited superior antibacterial activity compared to its phosphonic and non-desmethylated analogues when assayed in a chemically defined minimal medium.
๐ Specifically, the dipeptide L-Leu-D, L-Glu-ฮณ-PH showed significant antibacterial activity at a concentration of 2 ยตg/mL, which falls between the activity shown by the non-desmethylated (0.1 ยตg/mL) and phosphonic (80 ยตg/mL) analogues.
๐ The same dipeptide also showed comparable antibacterial properties to the well-known antibiotic amoxicillin when tested against Bacillus subtilis.
These results highlight the potential of the phosphinic pharmacophore for the development of novel antimicrobial drugs.
๐ This study contributes to antibiotic stewardship programs by offering a new potential direction for the development of antimicrobials. By investigating the antibacterial potential of phosphinic derivative dipeptides, the study illuminates the utility of targeting bacterial central metabolism, thus providing an innovative technique for managing multidrug resistance in bacteria.
Link to the article : https://bit.ly/45BCHBk
