๐ก The primary objective of this study was to examine the antibacterial activity of peptide derivatives of phosphinothricin against Multidrug-Resistant ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ.
๐ Using the Agar Diffusion method, researchers assessed the antimicrobial efficacy of Bialaphos, L-Leu-L-PT, and twelve other antibiotics against ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ ATCC 13883 and multidrug-resistant clinical isolates, applying varied doses of these substances to paper discs on an agar plate containing the bacteria.
๐ Phosphinothricin, in the form of its peptide derivatives, L-Leu-L-PT and Bialaphos, exhibits effective inhibitory activity against multidrug-resistant clinical isolates of ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ.
These ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ strains were not initially sensitive to twenty-four commonly used antibiotics of different classes.
๐ The process of nitrogen assimilation (specifically via glutamine biosynthesis) is identified as crucial to the growth of ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ and considered a potential target to inhibit the proliferation of multidrug-resistant strains.
๐ These findings make both Bialaphos and L-Leu-L-PT potential candidates for further development as effective antibiotic agents, particularly against multidrug-resistant bacteria.
๐ The study indicates that peptide derivatives of phosphinothricin might present a promising approach in battling multidrug-resistant bacterial strains, such as ๐๐ญ๐ฆ๐ฃ๐ด๐ช๐ฆ๐ญ๐ญ๐ข ๐ฑ๐ฏ๐ฆ๐ถ๐ฎ๐ฐ๐ฏ๐ช๐ข๐ฆ.
๐ This research contributes to the antibiotic stewardship field by offering potential solutions to tackle multidrug-resistant bacterial infections, a significant challenge in the current medical landscape. This insight could guide novel therapeutic strategies and contribute to the mitigation of antibiotic resistance.ย
Link to the article : https://tinyurl.com/yc8fdw49
