Human microbiome in health is not limited to microbes in our gut. The mitochondria in our cells are believed to have evolutionary roots as alpha-proteobacteria and the interaction between gut microbiome metabolites and cellular mitochondria might be a fundamental mechanism by which our body senses environmental cues. A common denominator and to metabolic dysfunction in both under and overnutrition may be bioactives – fermentable fibers, bioactive fats, phytonutrients, and fermentation products, these are largely missing from our diet due to food processing and disruption of the natural food matrix. The gut microbiome serves as a biological sensor for nutrients and communicates through bioactive signals with their endosymbiotic microbial cousins – the mitochondria. Authors in this study, provide a framework for addressing key knowledge and nutritional gaps in our understanding of bioactives, that may address future guidelines, labels, and food that impact under and over nutrition, and are inspiring next-generation nutritional approaches for addressing over- and undernutrition.
Link to the article: bit.ly/3GMGulQ
Published On: /04/2023
