Type 2 diabetes(T2D) is a worldwide health threat, a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. Gut commensal microbiota have been found to play a crucial role in the regulation of T2D. C. albicans, prominent opportunistic pathogen and a common gut symbionts gavage enhance the relative abundance of genus Staphylococcus spp. , which produces mounts of lipopollysaccharides, this can enter the blood stream through the impaired barrier of the gut mucosa, thus induce chronic low-grade inflammation (CLGI), a key mediator of the development of obesity, insulin resistance, and diabetes. Researchers, in this this study, observed that gut mycobiota play an important role in the progress of T2D and indicated that the improvement of C. albicans is a promising strategy to alleviate T2D and related metabolic dysfunctions.
Link to the article: bit.ly/3EOunUm
Published On: 02/03/2023