๐ก Researchers explore and analyze the distinct gut microbiome of rectum differences between anal healthy individuals, providing clues for the roles of gut microbiome of rectum in anal fistula patients.
๐ Anal fistula is a common proctological disease, the disruption of the balance of the gut microbiome plays an important role in the pathogenesis of anal fistula. The intestinal microbiome plays important roles in maintaining intestinal homeostasis. The disruption of the balance of the gut microbiome can lead to the intestinal diseases like colorectal cancer and inflammatory bowel diseases.
๐ The biodiversity of gut microbiome in the rectum revealed significant difference between anal fistula patients and healthy individuals. ๐บ๐๐๐๐๐๐๐๐๐๐๐๐ was enriched in anal fistula patients, while ๐ท๐๐๐๐๐๐๐๐๐๐๐๐๐ was higher in healthy individuals. The increase in the relative abundance of ๐บ๐๐๐๐๐๐๐๐๐๐๐๐ may cause persistent inflammation, which can lead to the anal fistula.
๐ ๐ท๐๐๐๐๐๐๐๐๐๐๐๐๐ may a protective factor for the anal fistula, just like the infection of Helicobacter pylori is a protective factor for Crohnยดs disease. Researchers in this study explored the distinct gut microbiome of rectum in anal fistula patients, using the 16S rRNA gene sequencing to test the microbiome samples extracted from the intestinal swab.
๐ด A diagnostic prediction model was constructed by random forest classifier, and the area under curve (AUC) reached 0.990, suggesting that the diagnostic prediction model based on the microbiota of gut microbiome had high accuracy and may provide innovative biomarkers for anal fistula patients.
This study gave an important hint for analyzing gut microbiome of rectum in anal fistula patient.
Link to the article: bit.ly/3X27PHG
Published On: /06/2023
