𝐑𝐞𝐯𝐢𝐭𝐚𝐥𝐢𝐳𝐢𝐧𝐠 𝐌𝐲𝐨𝐜𝐚𝐫𝐝𝐢𝐭𝐢𝐬 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐓𝐡𝐫𝐨𝐮𝐠𝐡 𝐆𝐮𝐭 𝐌𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐭𝐚 𝐌𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧

💡 Researchers explore ways of harnessing the gut microbiota as a potential therapeutic target in the treatment of myocarditis.

📌 Myocarditis is an inflammatory disease, characterized by the infiltration of inflammatory cells and deterioration of cardiac function. The clinical manifestations of myocarditis can vary from asymptomatic or subclinical/clinical symptoms to sudden death due to the damage of cardiomyocytes, inflammatory reaction, and myocardial fibrosis.

📌 Immune modulation is a novel treatment approach that includes the use of probiotics, prebiotics, and synbiotics to modulate the gut microbiota, as well as fecal microbiota transplantation to restore a healthy microbial balance. These approaches aim to improve the overall gut health and immune response, which may have a positive impact on myocarditis treatment outcomes.

📌 Gut microbiota dysbiosis can also induce an inflammatory response and affect the metabolism of bile acids, short-chain fatty acids, trimethylamine-N-oxide and other bioactive molecules, resulting in systemic inflammation and endothelial dysfunction. These changes, in turn, promote the development of atherosclerotic plaques and increase the risk of thrombosis and cardiovascular events.

📌 The gut microbiome is highly individualized, and bacterial composition can vary widely from person to person, personalized treatment plans that take into account the specific bacteria present in each patient’s gut microbiome are needed.

🔍 Precision medicine approaches, such as genomics, metabolomics, and various omics techniques can help in identifying specific bacterial strains that are associated with myocarditis and develop personalized treatment plans.

🔴 Researchers in this study, explore the gut microbiota-immune system-myocarditis axis of using the gut microbiota as a potential therapeutic target in the treatment of myocarditis.

Link to the article: bit.ly/3oHKwGl

Published On: /06/2023