Alterations in the gut microbiome contribute to the development and progression of cerebrovascular disease via the microbiota-gut-brain axis (GBA). The species and composition of gut microbiota and its metabolites are intrinsically linked to vascular inflammation and immune responses. Ecological imbalances of the gut microbiota can disrupt the integrity of the intestinal barrier, allowing pathogens and toxic metabolites to invade the systemic circulation, resulting in the dysregulation of GBA. The ensuing immune system dysregulation and neuroinflammation can induce neurotoxic misfolded proteins to accumulate around neurons, eventually triggering neuronal death. At the same time, central nervous system involvement can aggravate intestinal dysbacteriosis through defective autophagy-mediated, thus forming a vicious circle mediated by defective autophagy and immune system disorders. Authors in this study, discuss the impact of gut microbiota dysbiosis and its metabolites on cerebrovascular diseases, the molecular mechanisms of gut microbial metabolites in regulating the expression of specific interleukins in inflammatory immune responses. They further provide new insights for therapeutic treatments and standardized diagnosis and treatment of cerebrovascular diseases.
Link to the article : bit.ly/3Nbb1h3
Published On: /04/2023
