The asymptomatic gastrointestinal colonization of multidrug-resistant (MDR) bacteria, such as Klebsiella pneumoniae and Escherichia coli, presents a significant challenge in clinical settings due to their potential to cause difficult-to-treat infections. This study investigates the host factors influencing colonization using anβ¦
Bloodstream infections (BSIs) are life-threatening conditions that require prompt diagnosis and treatment. Current diagnostic methods for BSIs have long turnaround times, which can delay appropriate treatment and increase mortality. This study validates a Rapid Detection-Analysis Platform (RDAP) for the diagnosisβ¦
Autism Spectrum Disorder (ASD) is a multifactorial neurodevelopmental disorder marked by challenges with social interaction, repetitive behaviors, and communication deficits. ASD affects approximately one out of every 100 children worldwide. Individuals with ASD often have dysregulated gut microbial balance andβ¦
The gut virome, comprising primarily bacteriophages with some eukaryotic and archaeal viruses, plays a crucial role in maintaining gut homeostasis and influencing the immune system. Despite its importance, a comprehensive understanding of the gut virome in IBD, particularly across diverseβ¦
Coumarin, a phenolic compound and secondary metabolite produced by plants such as Tanga and Lime, exhibits a variety of biological activities including antimicrobial and anti-inflammatory effects. Coumarin derivatives have been synthesized via Pechmann condensation and investigated for their potential therapeuticβ¦
The escalation of antimicrobial resistance (AMR) due to the excessive and inappropriate use of antimicrobials has prompted the urgent need for more rapid and effective antimicrobial susceptibility testing (AST) methods. Conventional AST techniques often take 16β24 hours, leading to empiricalβ¦
In the face of the escalating global threat of antibiotic resistance, public health campaigns often resort to threat-based messaging. These campaigns paint vivid pictures of an apocalyptic future where antibiotics no longer work, aiming to reduce inappropriate antibiotic requests. Butβ¦
Migraine is a prevalent neurological disorder characterized by recurrent episodes of severe headache, often accompanied by nausea, vomiting, and heightened sensitivity to light and sound. Emerging evidence suggests that migraine involves complex metabolic processes and is influenced by the gutβ¦
Gestational diabetes mellitus (GDM) is a common condition affecting pregnant women, particularly those with pre-existing obesity and insulin resistance. The maternal microbiome undergoes significant shifts during pregnancy, which may impact metabolic health and pregnancy outcomes. This study investigates the impactβ¦
π π¦π³π΄πͺπ―πͺπ’ π±π¦π΄π΅πͺπ΄, the bacterium behind the plague, continues to be an important threat to public health, not only because of its historical significance, but also because of its developing antibiotic resistance. Understanding how this bacterium develops and spreads resistance isβ¦
Acute Coronary Syndrome (ACS) is a critical subset of coronary artery disease characterized by episodes of angina, myocardial infarction, and sudden cardiac death. The prevalence of ACS has reached pandemic levels globally, posing a significant public health burden. Recent studiesβ¦
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS) and is a leading cause of neurological disability in young adults. MS progression is influenced by a complex interplay of genetic and environmental factors, includingβ¦