Month April 2024

Vesicle protrusion induced by antimicrobial peptides suggests common carpet mechanism for short antimicrobial peptides

In the battle against antibiotic resistance, short-cationic alpha-helical antimicrobial peptides (SCHAMPs) have emerged as promising contenders. These peptides are short in sequence, target bacteria selectively, and act swiftly by rupturing bacterial membranes. To unlock their full potential, understanding their mechanism…

𝐃𝐢𝐞𝐭 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐠𝐮𝐭 𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐦𝐞 𝐢𝐧 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐰𝐢𝐭𝐡 𝐏𝐚𝐫𝐤𝐢𝐧𝐬𝐨𝐧’𝐬 𝐝𝐢𝐬𝐞𝐚𝐬𝐞

Parkinson’s disease (PD) has been linked to alterations in the gut microbiota, possibly mediated through the gut-brain axis. This study aimed to investigate the associations between diet quality, fiber intake, added sugar intake, and gut microbiome composition, as well as…

𝐁𝐞𝐧𝐞𝐟𝐢𝐜𝐢𝐚𝐥 𝐚𝐧𝐝 𝐢𝐦𝐦𝐮𝐧𝐨𝐦𝐨𝐝𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐞𝐟𝐟𝐞𝐜𝐭𝐬 𝐨𝐟 𝐡𝐞𝐚𝐭-𝐤𝐢𝐥𝐥𝐞𝐝 𝑳𝒂𝒄𝒕𝒐𝒃𝒂𝒄𝒊𝒍𝒍𝒖𝒔 𝒑𝒍𝒂𝒏𝒕𝒂𝒓𝒖𝒎 𝑳137 𝐢𝐧 𝐧𝐨𝐫𝐦𝐚𝐥 𝐚𝐧𝐝 𝐚𝐜𝐮𝐭𝐞 𝐜𝐨𝐥𝐢𝐭𝐢𝐬 𝐦𝐢𝐜𝐞

Postbiotics, such as heat-killed probiotic bacteria, have gained attention for their potential health benefits, offering advantages over traditional probiotics in terms of safety, production, and storage. In this study, researchers investigated the therapeutic effects of the postbiotic, Heat-killed Lactobacillus plantarum…

Virulence, antibiotic resistance phenotypes and molecular characterisation of 𝑽𝒊𝒃𝒓𝒊𝒐 𝒇𝒖𝒓𝒏𝒊𝒔𝒔𝒊𝒊 isolates from patients with diarrhoea

𝘝𝘪𝘣𝘳𝘪𝘰 𝘧𝘶𝘳𝘯𝘪𝘴𝘴𝘪𝘪, an emerging human pathogen is associated with cases of acute gastroenteritis. While 𝘝𝘪𝘣𝘳𝘪𝘰 𝘧𝘶𝘳𝘯𝘪𝘴𝘴𝘪𝘪 infections are traditionally considered rare, recent discoveries of multidrug-resistant strains have raised concerns regarding their clinical significance. This report provides a comprehensive analysis of…

𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐁𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡: 𝐃𝐞𝐞𝐩 𝐋𝐞𝐚𝐫𝐧𝐢𝐧𝐠 𝐌𝐨𝐝𝐞𝐥 𝐏𝐫𝐞𝐝𝐢𝐜𝐭𝐬 𝐀𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜 𝐑𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞 𝐟𝐫𝐨𝐦 𝐑𝐚𝐰 𝐌𝐚𝐬𝐬 𝐒𝐩𝐞𝐜𝐭𝐫𝐨𝐦𝐞𝐭𝐫𝐲 𝐃𝐚𝐭𝐚

Antimicrobial resistance (AMR) poses a global health threat, necessitating early and accurate treatment strategies. Mass spectrometry (MS), particularly MALDI-TOF, is widely used in clinical microbiology to identify bacterial species and detect AMR. However, existing AMR prediction models often rely on…

𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐔𝐧𝐭𝐡𝐢𝐧𝐤𝐚𝐛𝐥𝐞: 𝐋𝐢𝐟𝐞 𝐖𝐢𝐭𝐡𝐨𝐮𝐭 𝐭𝐡𝐞 𝐆𝐮𝐭 𝐌𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐦𝐞

The gut microbiome, comprising trillions of microorganisms residing in the human gastrointestinal tract, plays a fundamental role in maintaining various aspects of human health. From aiding in digestion and nutrient absorption to regulating immune function and influencing brain activity, the…