𝐄𝐟𝐟𝐢𝐜𝐚𝐜𝐲 𝐨𝐟 𝐄𝐧𝐳𝐲𝐦𝐚𝐭𝐢𝐜𝐚𝐥𝐥𝐲 𝐃𝐞𝐫𝐢𝐯𝐞𝐝 α-𝐀𝐦𝐢𝐧𝐨𝐩𝐡𝐨𝐬𝐩𝐡𝐨𝐧𝐚𝐭𝐞𝐬 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐌𝐮𝐥𝐭𝐢𝐝𝐫𝐮𝐠-𝐑𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐭 𝐍𝐨𝐬𝐨𝐜𝐨𝐦𝐢𝐚𝐥 𝐏𝐚𝐭𝐡𝐨𝐠𝐞𝐧𝐬: 𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐀𝐥𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐯𝐞𝐬 𝐭𝐨 𝐂𝐮𝐫𝐫𝐞𝐧𝐭 𝐀𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜𝐬 

💡 The paper discusses the evaluation of antibacterial activity against nosocomial pathogens.  

📌 The study addressed two pharmacophores (coumarins and α-amino dimethyl phosphonate moieties) to test their synergy and antimicrobial activity against selected strains of multidrug-resistant nosocomial pathogenic bacteria.  

📌 The study aimed to identify how the structure of coumarin α-aminophosphonate influences its antibacterial activity and to find effective, non-selective compounds for treating multidrug-resistant pathogens. 

📌 The researchers synthesized α-aminophosphonates using an enzyme-catalysed protocol, then tested the compounds on selected bacterial strains using Minimum Inhibitory Concentration and Minimum Bactericidal Concentration assays. The impact on bacterial DNA was also analyzed. 

📌 The synthesized α-aminophosphonates interacted noticeably with bacterial cells.  

📌 The compounds showed significant antimicrobial activity against both Gram-positive 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 and several Gram-negative bacteria strains.  

📌 The Minimum Inhibitory Concentration for the Gram-negative strains tested ranged from 2-8.3 µM.  

📌 Compounds 4 and 5 presented nonselective antimicrobial activity, effective against multidrug-resistant pathogens.  

📌 The introduction of a trifluoromethyl group or a phosphonate moiety increased antimicrobial activity.  

📍 All tested compounds functioned as bactericidal agents.  

📌 Several synthesized α-aminophosphonates showed higher antimicrobial activity than existing antibiotics, particularly against 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴. 

📌 The newly synthesized α-aminophosphonates showed significant antimicrobial activity against selected bacterial strains, particularly 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴. Compounds 4 and 5 exhibited nonselective antimicrobial activity, making them potential candidates for use against various types of multidrug-resistant pathogens.

The presence of the trifluoromethyl group in the coumarin structure and the introduction of a phosphonate moiety significantly enhanced the compounds’ antimicrobial activity. The study’s results suggest that these α-aminophosphonates may serve as alternatives to existing antibiotics for treating nosocomial and clinical infections. 

LInk to the article : https://tinyurl.com/yvdrukw3