๐ก Researchers explore the relationship between intestinal microbiota and abnormal lipid metabolism in Spinal muscular atrophy (SMA).
๐ SMA is an autosomal recessive neuromuscular disease, a hereditary disorder with multiple system dysfunction, especially lipid metabolic disorders.
๐ The gut microbiota regulates a series of key metabolic functions of the body, and its dysbiosis plays an important role in modulating metabolic disturbances.
๐ In addition to the microbiome and metabonomic analyses, the Spearman correlation indicated that alterations in the expression of lipid metabolites might be linked to those in differential microbiota, particularly the genera Ruminiclostridium and Gordonibacter. These bacteria were found to be linked to fatty acid degradation and elongation, linoleic acid metabolism, arachidonic acid metabolism, among others, by negatively regulating the lipid metabolite expression.
๐ด Researchers in this study, explore the differences in the intestinal microbiota of patients with SMA compared with healthy subjects, investigate the abnormal expression of lipid metabolites in these patients, and study the relationship between intestinal microbiota and abnormal lipid metabolism.
They further provide a clinical basis to explore the pathological mechanism and the potential management of lipid metabolic disorders in SMA.
Link to the article: bit.ly/3OFL0Ab
Published On: /06/2023
