๐ก The study aimed to evaluate the efficacy of the probiotic ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด (๐. ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด) in reducing ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด (๐. ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด) colonization in human intestines and nares, addressing the limitations of previous decolonization strategies.
๐ Methods:
๐ Trial Design: Single-center, phase 2, double-blind, randomized, placebo-controlled trial.
๐ Participants: Adults from Songkhla, Thailand, colonized by ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด, without recent antibiotic treatment or intestinal diseases.
๐ Intervention: Participants received 250 mg of ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด MB40 or placebo daily for 30 days.
๐ Outcome Measures: Primary outcome was ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด colonization reduction in the intestine (faecal counts) and nares (nasal swabs).
๐ Key Scientific Findings:
๐ Probiotic Efficacy: ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด probiotic led to a significant reduction of ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด in stool (96.8%) and nose (65.4%).
The intervention targeted intestinal ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด colonization, showcasing a novel approach compared to traditional nose and skin-focused strategies.
๐ Safety and Microbiome Impact: No severe adverse effects were reported, and overall microbiome composition remained unaffected.
The probiotic strategy demonstrated safety and efficacy without causing harm to the existing microbiota.
๐ Quantitative Analysis: Colonization densities in the intestine were reduced by an average factor of approximately 31, highlighting the potency of the probiotic.
The study used quantitative data, distinguishing it from previous qualitative approaches.
๐ Long-Term Applicability: Prolonged intake of ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด could potentially yield more pronounced effects, considering the transient nature of Bacillus colonization.
The probiotic strategy allows for long-term application without harmful side effects, a notable advantage over short-term antibiotic procedures.
๐ Intestinal Dominance in Colonization: The study emphasized the overwhelming importance of the intestinal colonisation site for overall ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด colonisation, based on quantitative data.
Reduction of nasal colonization suggested a dominating role of the intestinal site in ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด dynamics.
๐ Implications for Future Strategies: ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด probiotic offers a previously unavailable method for eradicating the main intestinal reservoir of ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด.
The findings support a shift towards intestinal-focused decolonization efforts, challenging conventional strategies targeting the nose and skin.
๐ The study establishes the efficacy and safety of the ๐๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด ๐ด๐ถ๐ฃ๐ต๐ช๐ญ๐ช๐ด probiotic in reducing ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด colonization, presenting a promising alternative for individuals at risk of recurring ๐๐ต๐ข๐ฑ๐ฉ๐บ๐ญ๐ฐ๐ค๐ฐ๐ค๐ค๐ถ๐ด ๐ข๐ถ๐ณ๐ฆ๐ถ๐ด infections. The focus on intestinal colonization dynamics calls for a reevaluation of decolonization strategies, emphasizing the potential of probiotics in long-term applications without adverse effects on the microbiota.
Link to the article : http://tinyurl.com/4935fxpt
